-
A new study indicates the possibility to monitor the progression of Alzheimer's disease by monitoring major brain antioxidant levels using noninvasive techniques
on October 12, 2018 at 10:08 pm
In a breakthrough human study, anti-oxidant, glutathione (GSH), which protects the brain from stress, has been found to be significantly depleted in Alzheimer's patients compared to normal subjects. As GSH is a very important anti-oxidant that protects the brain from free radicals, the findings give us another measure to use when diagnosing potential for the advancement of Alzheimer's disease or recognizing those that are in the throes of Alzheimer's advancement. […]
-
Oscillations provide insights into the brain's navigation system
on October 12, 2018 at 3:02 pm
The brain creates a map of our environment, which enables reliable spatial navigation. The Nobel Prize was awarded in 2014 for research into how this navigation system works at the cellular level. Researchers have now shown that the characteristics of this navigation system are also present in brain oscillations that can be measured using depth electrodes in the human brain. The possibility of testing the neuronal navigation system in this way may open up new approaches for the early diagnosis of Alzheimer's disease. […]
-
How the grid cell system of the brain maps mental spaces
on October 12, 2018 at 2:22 pm
How exactly the grid cell system works in the human brain, and in particular with which temporal dynamics, has until now been speculation. A much-discussed possibility is that the signals from these cells create maps of 'cognitive spaces' in which humans mentally organize and store the complexities of their internal and external environments. A team of scientists has now been able to demonstrate, with electrophysiological evidence, the existence of grid-like activity in the human brain. […]
-
Early changes to synapse gene regulation may cause Alzheimer's disease
on October 12, 2018 at 1:29 pm
New research has revealed a role for splicing proteins in the pathology of Alzheimer's disease. Increased phosphorylation of the SRRM2 protein, seen in AD mouse models and human patients, was found to block its transport to the nucleus. This reduced levels of the PQBP1 protein, causing abnormal changes to the splicing of synapse genes and cognitive decline. These phenotypes were reversed by restoring PQBP1 function, suggesting a possible future treatment for AD. […]
-
Early changes to synapse gene regulation may cause Alzheimer's disease
on October 12, 2018 at 1:29 pm
New research has revealed a role for splicing proteins in the pathology of Alzheimer's disease. Increased phosphorylation of the SRRM2 protein, seen in AD mouse models and human patients, was found to block its transport to the nucleus. This reduced levels of the PQBP1 protein, causing abnormal changes to the splicing of synapse genes and cognitive decline. These phenotypes were reversed by restoring PQBP1 function, suggesting a possible future treatment for AD. […]
